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What is Suboxone (Buprenomorphine and Naloxone)

Suboxone (Buprenomorphine and Naloxone) contains 2 medicines: buprenorphine and naloxone. It is used to treat opioid (narcotic) dependence / addiction. Buprenorphine belongs to a class of drugs called mixed opioid agonist-antagonists. Buprenorphine helps prevent symptoms caused by stopping other opioids.

How does Suboxone work? What are its effect?

This combination medicine contains 2 active ingredients: buprenorphine and naloxone.

Buprenorphine belongs to the group of medications called partial opiate agonists.

Naloxone belongs to the group of medications known as opiate antagonists.

This combination of drugs is used in conjunction with a comprehensive addiction treatment program that includes medical, social and psychological support to treat adults who are addicted to opiates (narcotics) such as oxycodone or morphine. A narcotic-dependent person who stops taking the narcotic abruptly is likely to experience significant withdrawal symptoms.

Buprenorphine works by replacing the physical effects of the narcotic that the person is dependent on, which can help facilitate the treatment of his addiction. Naloxone is added to the drug to prevent drug abuse (ie to prevent it from being injected into a vein). Naloxone has no effect when administered under the tongue as intended. But if you abuse the drug and inject it into a vein (which is colloquially known as “shooter”), naloxone will work by blocking the effects of buprenorphine, which will lead to withdrawal symptoms.

Suboxone is available under various brand names or in different presentations. A specific brand of this medication may not be available in all forms or approved for all conditions mentioned here. In addition, some forms of this medicine may not be used against all conditions mentioned in this article.

Your doctor may have suggested this medicine for a condition not listed in this drug information article. If you have not discussed this with your doctor, or if you are not sure why you are taking this medicine, check it out.

Do not give this medicine to anyone, even someone who has the same symptoms as yours. This medication may be harmful to people for whom it has not been prescribed. Do not stop taking this medicine without first consulting your doctor.

How should Suboxone be used?

This medicine should only be prescribed by a doctor authorized to do so because it meets certain specific criteria for its use. The dose of this medication varies with your personal circumstances and your doctor will adjust it as needed.

The recommended starting dose is 4 mg (buprenorphine) once daily. The maximum daily dose is 24 mg. Over time, your doctor may reduce your dose gradually until you stop taking the medicine. Do not adjust the dose and stop taking the medication on your own.

Buprenorphine – naloxone is used for a minimum period of 2 months. Do not stop taking the medication on your own. When it is time to stop using buprenorphine-naloxone, your doctor will advise you how to gradually reduce the dose to avoid withdrawal symptoms.

The drug is placed under the tongue until it dissolves (which usually takes 2 to 10 minutes). Do not swallow the tablets. If you need to take more than 1 tablet at a time, place the tablets under the tongue at the same time.

It is important to use this medicine as directed by your doctor. If you miss a dose, contact your doctor for instructions. Do not use a double dose to compensate for a missed dose.

There are several factors that can be considered in determining the dose a person needs: weight, health, and other medications. If your doctor has recommended a dose other than those listed here, do not change the way you take the medicine without first consulting it.

Store this medication at room temperature, away from light and moisture and out of the reach and sight of children. The accidental intake of this medication by a child is a medical emergency and can lead to death.

Do not dispose of medicines in waste water (eg, in the sink or in the toilet bowl) or with household waste. Ask your pharmacist how to get rid of unused or expired medications.

In which cases is this medicine not recommended?

The buprenorphine – naloxonene combination therapy should not be used in the following circumstances:

is allergic to buprenorphine, naloxone, or to any of the ingredients of the medication
the presence of acute alcoholism;
a delirium tremens;
no regular intake of opioid analgesics;
greatly reduced hepatic function
pulmonary function (breathing) severely reduced.

What are the possible side effects of Suboxone?

Many medications can cause side effects. A side effect is an undesirable response to a drug when taken at normal doses. It can be mild or severe, temporary or permanent.

The side effects listed below are not felt by everyone who takes this medicine. If you are worried about side effects, discuss the risks and benefits of this medicine with your doctor.

At least 1% of people taking this medicine have reported the following side effects. A lot of these side effects can be taken care of and a few can go away on their own with time.

Consult your doctor if you experience these side effects and if they are serious or bothersome. Your pharmacist may be able to give you advice on what to do if these side effects occur:

gastric pain;
a state of general weakness or drowsiness;
dizziness when moving from a sitting or lying position to a standing position;
loss of appetite
sleep disorders;
Most of the side effects listed below do not occur very often, but they could cause serious problems if you do not receive medical care.

Check with your doctor as soon as possible if any of the following side effects occur:

a drop in blood pressure;
the confusion;
swelling of hands or feet
rash, hives;
hallucinations (eg the illusion of hearing, seeing or feeling something that does not really exist);
signs of depression (eg, lack of concentration, weight fluctuations, changes in sleep, disinterest in many activities, suicidal thoughts)
symptoms of low blood sugar (eg cold sweats, pallor and freshness of the skin, headache, fast heartbeat, weakness)
symptoms of liver problems (such as yellowing of the whites of the eyes or skin, abdominal pain, loss of appetite, pale stools, itchy skin, or dark urine)
symptoms of high blood sugar (eg, frequent urination, increased thirst, excessive appetite, unexplained weight loss, poor healing wounds, infections, fruity breath)
Stop taking the medication and seek immediate medical attention if there is an answer such as:

chest pain
feeling unconscious, dizziness, mental confusion, or unusual symptoms;
signs of overdose (eg, cold, clammy skin, confusion, tremors, nausea, low and rapid pulse, gait disturbances, breathing difficulties, flaccidity (softness) ) muscles);
slower than normal breathing or difficulty breathing
symptoms of a serious allergic reaction (such as swelling of the face or throat, hives, wheezing or difficulty breathing)

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